Let’s talk Rhesus – cause education can save lives! This is miscarriage at a ve…

Let’s talk Rhesus – cause education can save lives!
This is miscarriage at a very early gestational age – around 8 weeks.
The fetus was spontaneously aborted and the mother was found to be Rhesus factor negative while her fetus was Rh-positive.
There are a few important preventive measures that can be done in order to save subsequent pregnancies.
In general, the rhesus blood group system is composed of 5 antigens, with the D antigen being the most immunogenic and hence commonly involved in fetal disease.
The placenta acts as a barrier between the mother and the fetus, but fetal erythrocytes may enter her circulation secondary to detonate tank hemorrhage during the course of an abortion (spontaneous or induced) as well as during normal delivery, trauma, and invasive procedures like amniocentesis.
So, Rh antigen alloimmunization or incompatibility occurs when Rh-positive fetal erythrocytes enter the bloodstream of an Rh-negative pregnant woman and the woman develops antibodies against the D antigen present on the fetal erythrocytes.
Although these antibodies do not affect the fetus of this index pregnancy, they are potentially hazardous in subsequent pregnancies. If the alloimmunized woman hets pregnant with an Rh-positive fetus, her antibodies will bind and lyse (destruct) the fetal erythrocytes.
Therefore, to prevent this, the unsensitized Rh-negative pregnant woman should receive anti-immune globulin (RhoGAM) to lower her risk of incompatibility and development of hemolytic disease of the newborn in the subsequent pregnancy.
RhoGAM shot is administered at these critical times (abortion, delivery), which bind the D antigens on the fetal erythrocytes in the mother’s circulation and prevents the formation of antibodies, so they cannot cross and affect the next pregnancy.
Photo by @goldansilva

Source by medicaltalks


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